Preheat the oven to 350 degrees Fahrenheit and line 2 baking sheets with parchment paper.
Mix the flour, baking soda, baking powder and salt in a bowl, set aside.
In a standing mixer with paddle attachment cream the butter and sugars at medium speed for about 2 minutes.
Add peanut butter to the mixer and mix for an additional 30 seconds.
Add eggs, one at a time, and mix after each addition.
Add in the vanilla and mix until combined.
Turn the speed of the mixer down to low/stir and slowly add in the dry ingredients. Stir until just combined.
Stir in the butterscotch chips.
Form dough into approximately 2 inch diameter balls and place on parchment lined baking sheets approximately 2 1/2 inches apart. Press criss cross design into the dough balls with a fork.
Bake for approximately 10 minutes. When edges start to become golden brown they are done.
Remove from oven and allow to rest on baking sheet for about 5 minutes.
Transfer cookies gently to a wire cooling rack until cool.